Formulation and evaluation of chewable modified-release tablet containing sodium fluoride and vitamin C
نویسندگان
چکیده
Chewable modified release tablets containing two active ingredients vitamin C (200mg) and Sodium Fluoride (2mg) were formulated for the treatment of dental diseases. Other ingredients include Mannitol, Carbopol and Hydroxyl-Propyl Methylcellulose (HPMC), in different ratios. These tablets were prepared by direct mixing of Hydroxypropyl Methylcellulose (HPMC), vitamin C, Sodium Fluoride, Carbopol, Mannitol and Magnesium Stearate by pressing through single punch machine. Their dissolution properties were assessed using USP (paddle apparatus).In order to investigate the mode of drug release from the tablets, the release data were subjected to various release kinetic models. The modified release strength of the tablets was also evaluated. The results showed that the combination of two polymers give a satisfactory drug release. This new formulation can be administered either by swallowing the whole tablet or by chewing the tablet beacause controlled release properties of this formulation do not change by chewing the tablet. Such type of tablets could be valuable for all patients including those who have difficulty in swallowing, for example pediatrics and geriatrics patients.
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